Journal article Open Access

FORMULATION, DEVELOPMENT AND EVALUATION OF TAZAROTENE INVASOME GEL FOR TREATMENT OF TOPICAL DISEASE

Pragya Sharma*, Priyanka Namdeo, Dr. Govind Nayak, Dr. Parul Mehta


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <controlfield tag="005">20220725014904.0</controlfield>
  <controlfield tag="001">6893805</controlfield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">952487</subfield>
    <subfield code="z">md5:83e023790c6288be311af14c64e3f432</subfield>
    <subfield code="u">https://zenodo.org/record/6893805/files/52.paper pragya.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2022-07-24</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="o">oai:zenodo.org:6893805</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Pragya Sharma*, Priyanka Namdeo, Dr. Govind Nayak, Dr. Parul Mehta</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">FORMULATION, DEVELOPMENT AND EVALUATION OF TAZAROTENE INVASOME GEL FOR TREATMENT OF TOPICAL DISEASE</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;&lt;em&gt;In the tropics, infectious diseases that either occurs exclusively or more frequently in humid and subtropical climates are either more prevalent or more difficult to prevent or manage. A type of vesicular system called invasomes exhibits greater transdermal penetration than conventional liposomes. These vesicles&amp;#39; structures contain phospholipids, ethanol, and terpene, which provide the soft vesicles good transdermal penetration properties. These nanovesicles&amp;#39; ability to increase drug permeability into the epidermis while reducing absorption into the systemic circulation, hence restricting drug action within the skin layer, is one of its main advantages. In present study was to develop and characterize &lt;/em&gt;&lt;em&gt;Tazarotene&lt;/em&gt;&lt;em&gt; -loaded invasomal drug carrier systems. Different Formulations (F1 to F6) of invasomes were prepared and evaluated for &lt;/em&gt;&lt;em&gt;average vesicle size, zeta potential and entrapment efficiency.&lt;/em&gt;Drug content of Tazarotene incorporated invasomes gel for formulation TIG-1, TIG-2 and TIG-3 was found to be&lt;em&gt;97.85&amp;plusmn;0.32&lt;/em&gt;, &lt;em&gt;99.12&amp;plusmn;0.25 &lt;/em&gt;&lt;em&gt;and &lt;/em&gt;&lt;em&gt;98.74&amp;plusmn;0.14 &lt;/em&gt;&lt;em&gt;respectively. The maximum drug content was found in formulation TIG-2 (&lt;/em&gt;&lt;em&gt;99.12&amp;plusmn;0.25&lt;/em&gt;&lt;em&gt;), select as optimized formulation.&lt;/em&gt;&lt;em&gt;When the regression coefficient values of were compared, it was observed that &amp;lsquo;r&lt;sup&gt;2&lt;/sup&gt;&amp;rsquo; values of &lt;/em&gt;&lt;em&gt;Higuchi &lt;/em&gt;&lt;em&gt;was maximum i.e.&lt;/em&gt;&lt;em&gt;0.994 &lt;/em&gt;&lt;em&gt;hence indicating drug release from formulations was found to follow &lt;/em&gt;&lt;em&gt;Higuchi &lt;/em&gt;&lt;em&gt;kinetics.&lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Invasome, &lt;/em&gt;&lt;em&gt;Tazarotene&lt;/em&gt;&lt;em&gt; , Topical disease, Formulation, Evaluation&lt;/em&gt;&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="i">isVersionOf</subfield>
    <subfield code="a">10.5281/zenodo.6893804</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.6893805</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
</record>
12
10
views
downloads
All versions This version
Views 1212
Downloads 1010
Data volume 9.5 MB9.5 MB
Unique views 1212
Unique downloads 1010

Share

Cite as