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PRELIMINARY INVESTIGATION OF BIOACTIVE CONSTITUENTS AND EVALUATION OF ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF AGAVE SISALANA

Apurva Pandya*, Ms. Priya Bisen, Dr. Manjeet Singh, Dr. Rajesh Mujoriya


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    <subfield code="a">&lt;p&gt;&lt;em&gt;Pyrexia or fever is caused as a secondary impact of infection, malignancy or other diseased states. It is the body&amp;#39;s natural defense to create an environment where infectious agent or damaged tissue cannot survive. &lt;/em&gt;&lt;em&gt;In present study, the antipyretic activity of ethanol extracts from Agave sisalana was evaluated using Brewer&amp;#39;s yeast induced pyrexia in rats. The results showed that the ethanolic extract of Agave sisalana possesses a significant antipyretic effect in maintaining normal body temperature and reducing yeast-induced elevated body temperature in rats in a dose dependent manner and its effect is comparable to that of the standard antipyretic drug paracetamol. &amp;nbsp;It was therefore concluded that the extracts of Agave sisalana demonstrated antipyretic activity, the ethanol extract was found to be potent than the aqueous extract. &lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Agave sisalana, Ethanolic extract, Antipyretic activity.&lt;/em&gt;&lt;/p&gt;</subfield>
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