The Role of Hydrocortisone and Lignocaine in Attenuating Pain on Propofol Injection with Different Times

Abstract
Background: Even with popularity of propofol in GA, pain on injection continues to be a distressing problem. Till now no any intervention  had lead to the complete reliefe of propofol injection pain. The pain is related to inflammatory response induced by propofol injection. Different methods and medication used to attenuate this pain.
Objective:  To compare the effect of HC and LG in attenuation of pain following i.v. injection of propofol at two time intervals.
Patient and method: A prospective, randomized, controlled, study was conducted on 100 adult patients belonging to ASA physical status I or II, scheduled to undergo elective surgery. They were randomly allocated to four equally groups of 25 each. Group LG20, group LG40, group HC20 and group HC40. These groups received 2ml 2% LG  20 sec, 2ml 2% LG 40 sec, 20 mg HC 20 sec. and 20mg HC 40 sec, prior to propofol injection, respectively. Propofol was injected at two time intervals (at 20sec & 40sec) later according to the corresponding group. Patients pain level was assessed using a four-point VRS. Result: There was no significant difference of hemodynamics changes during propofol induction between all groups. There was statistically significant difference in pain incidence between group LG40 and HC40. There was statistically significant difference in pain incidence between patients’ group LG20 and HC20 at 10 sec and 15 sec, but was not at 5 sec. There was no statistically significant difference in pain incidence between patients of the group HC20 & HC40, and between LG20 & LG40.
Conclusion: LG, was superior to HC in attenuating propofol injection pain. Time had failed to have an influence on the effect of both study drugs.