Journal article Open Access

EVALUATION OF ANTI DIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF IXORA COCCINEA LEAVES

Nimma Vijaya Reka, S.K. Godasu, P.Raju , Kyatham Hemanth, Uootukuru Ashwini

Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Ixora coccinea was made on the basis of its High therapeutic value. They are mostly shrubs and small trees that are part of the under-storey plant community in the tropical forest. The preliminary phytochemical investigation of powdered Ixora coccinea showed the presence of Carbohydrates, Alkaloids, Glycosides, Steroid, Terpenoids, Flavonoids, Proteins and Amino acids. The pharmacological and acute toxicity studies of ethanolic extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed upto 2000mg/kg of body weight. The Biological dose of extract Ixora coccinea dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity. Alloxan causes a massive destruction of β-cells of the islets of Langerhans, resulting in reduced synthesis and release of insulin. The function of the insulin suppressed, which leads to high level of hyperglycemic and eventually to death, but the different extracts of Ixora coccinea showed antidiabetic effect in alloxan induced diabetic rats and reduced the mortality rate significantly.

KEY WORDS: Ixora coccinea, Anti-diabetic activity, Leaves, Ethanolic extract

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