STUDY OF ANTI CONVULSANT ACTIVITY OF SYZYCIUM CUMINI LEAVES IN WISTER RATS

Epilepsy is a chronic CNS disorder characterized by brief episodes of seizures and excessive EEG discharge. Syzygium cumini used as a herbal medicine and is well known for its traditional uses such as expectorants, diuretics, laxative etc. The qualitative phytochemical analysis of ethanolic extract of Syzygium cumini. It contains alkaloids, Carbohydrates, Glycosides, Flavonoids, Terpenes, Tannins Proteins, Amino Acids. The Ethanol extract of Syzygium cumini delayed the onset and reduced the duration of convulsion in MES and PTZ induced convulsion models and can be used as an adjuvant therapy against cognitive deficit in convulsions. The extract also shows significant decrease in lipid peroxidation level and increase in reduced glutathione level, indicates that EESC possess good antioxidant activity. Also, EESC significantly increased the level of inhibitory neurotransmitter GABA and also showed increase in DA, NA and 5-HT levels. Hence it can be concluded that the EESC possesses good anticonvulsant activity. Further studies are needed to explore the mechanism as well as the active principle responsible for the anticonvulsant activity of Syzygium cumini.

KEY WORDS: Anticonvulsant activity, Syzygium cumini, Leaves, Epilepsy, Ethanolic extract