Journal article Open Access

REVIEW OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY

Dr. Bharat .V. Jain, Drx. Kajal Vipin Jain*, Dr. Sandip. R. Pawar, Mr. Tanveer.Y. Shaikhb


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  <identifier identifierType="DOI">10.5281/zenodo.6821620</identifier>
  <creators>
    <creator>
      <creatorName>Dr. Bharat .V. Jain, Drx. Kajal Vipin Jain*, Dr. Sandip. R. Pawar,  Mr. Tanveer.Y. Shaikhb</creatorName>
    </creator>
  </creators>
  <titles>
    <title>REVIEW OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-07-12</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/6821620</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.6821619</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;em&gt;The traditional dosage form has many limitations due to factors such as naso-lacrimal drainage &amp;amp; shorter contact time. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition. Environmental pH, temperature, &amp;amp; ionic strength, Response to environmental changes, the in- situ are liquids when installation into the eyes and then undergo rapidly gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. The goal of this study is to prepare and evaluate In- situ Gel for ocular drug delivery by using mucoadhesive polymers to increase ocular residence time and minimize Precorneal drugs loss of given formulation.&lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Keywords: &lt;/strong&gt;&lt;em&gt;Ocular Drug Delivery, In-situ Gelling System, Conjunctivitis.&lt;/em&gt;&lt;/p&gt;</description>
  </descriptions>
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