Journal article Open Access

EVALUATION OF ANTI-ULCER ACTIVITY OF THE EXTRACT OF TALINUM TRIANGULARE IN RATS

Rishikesh Choudhary, Balweer Singh Kirar, Dr. Alok Pal Jain


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    <subfield code="a">&lt;p&gt;&lt;em&gt;Preventive and therapeutic activities of Hydroalcoholic extract of Talinum triangulare leaves against ethanol-induced ulcer in wistar rats is the aim of this study. Fresh plants of T. triangulare were purchased from a local market in Bhopal,M.P and were identified by a botanist. The extraction was done using Soxhlet apparatus and (Ethanol: water; 80:20) as the solvent. The process was allowed to run for a total of 18 hours. Five groups (n = 6) of Wistar rats were used to study the anti-ulcer activity of Talinum triangulare Hydroalcoholic extract.&amp;nbsp; PBS, Hydroalcoholic extract, omeprazole and ethanol were administered to the animals per orally (p.o). Group 1 received PBS (10 mL/ kg) all over the experimental period (11 days) and served as control. Group 2 received PBS (10 mL/ kg) for 10 days and on the 11th day received absolute ethanol (5 mL/ kg) and served as ulcer control. Group 3 and 4 were respectively administered with 300 and 400 mg/kg Talinum triangulare Hydroalcoholic extract, group 5 with omeprazole (8 mg /kg) for 10 days. All the groups were fasted for 24 h and again administered with the extract or drug at respective dose. After 30 min of this treatment, animals of groups 2-5 were administered with 5 mL/ kg ethanol to induce ulcer. After 15 min of ethanol administration, all the animals were sacrificed using anesthetic ether.&amp;nbsp; Gastric volume was measured by pylorus ligation method. Each stomach was opened along the greater curvature and examined macroscopically for gastric erosions under a dissecting microscope (20 X). The length and width (mm) of ulcer on the gastric mucosa were measured by plane glass square (10&amp;times;10 mm). &lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Anti-ulcer Activity, Talinum triangulare, Pylorus ligation method&lt;/em&gt;&lt;/p&gt;</subfield>
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