Journal article Open Access

EVALUATION OF ANTI-ULCER ACTIVITY OF THE EXTRACT OF TALINUM TRIANGULARE IN RATS

Rishikesh Choudhary, Balweer Singh Kirar, Dr. Alok Pal Jain

Preventive and therapeutic activities of Hydroalcoholic extract of Talinum triangulare leaves against ethanol-induced ulcer in wistar rats is the aim of this study. Fresh plants of T. triangulare were purchased from a local market in Bhopal,M.P and were identified by a botanist. The extraction was done using Soxhlet apparatus and (Ethanol: water; 80:20) as the solvent. The process was allowed to run for a total of 18 hours. Five groups (n = 6) of Wistar rats were used to study the anti-ulcer activity of Talinum triangulare Hydroalcoholic extract.  PBS, Hydroalcoholic extract, omeprazole and ethanol were administered to the animals per orally (p.o). Group 1 received PBS (10 mL/ kg) all over the experimental period (11 days) and served as control. Group 2 received PBS (10 mL/ kg) for 10 days and on the 11th day received absolute ethanol (5 mL/ kg) and served as ulcer control. Group 3 and 4 were respectively administered with 300 and 400 mg/kg Talinum triangulare Hydroalcoholic extract, group 5 with omeprazole (8 mg /kg) for 10 days. All the groups were fasted for 24 h and again administered with the extract or drug at respective dose. After 30 min of this treatment, animals of groups 2-5 were administered with 5 mL/ kg ethanol to induce ulcer. After 15 min of ethanol administration, all the animals were sacrificed using anesthetic ether.  Gastric volume was measured by pylorus ligation method. Each stomach was opened along the greater curvature and examined macroscopically for gastric erosions under a dissecting microscope (20 X). The length and width (mm) of ulcer on the gastric mucosa were measured by plane glass square (10×10 mm).

Key words: Anti-ulcer Activity, Talinum triangulare, Pylorus ligation method

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