HEPATOPROTECTIVE AND NEPHROPROTECTIVE ACTIVITY OF PULP AND FLESH OF FRUIT OBTAINED FROM CHOEROSPONDIAS AXILLARIS (ROXB.) USING RIFAMPICIN AS AN INDUCER ON ALBINO RATS

Objective: The aim of the study was to investigate the hepato and nephro protective activity of Choerospondias axillaris (Roxb.) peel and flesh extract against Rifampicin induced toxicity in albino rat.

Methods: Bioactive functional groups, flavonoids, saponins, tannins, glycosides, polyphenols, carotenoids (provitamin A), vitamins C and E were present in hydroalcholic extract which was confirmed by respective chemical test and the hepato and nephroprotection activity of ethanolic extract was evaluated against Rifampicin (1g/kg body wt, p.o.). Biomarkers like, ALT, AST, were considered to determine hepatoprotecton. Nephroprotection activity was determine by measuring serum creatinine, uric acid, blood urea nitrogen. Histopathological study of liver and kidney was carried out.

Results: Hydroalcoholic extract of C.axillaries reduced the level of aspartate transaminase (AST) and alanine transaminase (ALT) in comparision to inducer. The extract also showed nephroprotective activity against rifampicin-induced nephrotoxicity by significantly reducing the levels of uric acid, blood urea nitrogen (BUN), serum creatinine. Histopathological studies of liver and kidney were  in agreement with biomarkers.

Conclusion: Keywords: Choerospondias axillaris, antioxidant and lapsi fruit.