Journal article Open Access

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NOVEL ISOXAZOLE BEARING PYRAZOLE DERIVATIVES FOR ANTIBACTERIAL ACTIVITY

Kamlesh Kumar Pandey, Alok Pal Jain, Amit Nayak*


JSON Export

{
  "files": [
    {
      "links": {
        "self": "https://zenodo.org/api/files/62d0b0df-0b0e-4dea-80d3-9913d87df4fc/8.Research%20Paper%201.pdf"
      }, 
      "checksum": "md5:085628f0b868b590a9504ef591e97a13", 
      "bucket": "62d0b0df-0b0e-4dea-80d3-9913d87df4fc", 
      "key": "8.Research Paper 1.pdf", 
      "type": "pdf", 
      "size": 1490771
    }
  ], 
  "owners": [
    159385
  ], 
  "doi": "10.5281/zenodo.6798462", 
  "stats": {
    "version_unique_downloads": 8.0, 
    "unique_views": 8.0, 
    "views": 8.0, 
    "version_views": 8.0, 
    "unique_downloads": 8.0, 
    "version_unique_views": 8.0, 
    "volume": 11926168.0, 
    "version_downloads": 8.0, 
    "downloads": 8.0, 
    "version_volume": 11926168.0
  }, 
  "links": {
    "doi": "https://doi.org/10.5281/zenodo.6798462", 
    "conceptdoi": "https://doi.org/10.5281/zenodo.6798461", 
    "bucket": "https://zenodo.org/api/files/62d0b0df-0b0e-4dea-80d3-9913d87df4fc", 
    "conceptbadge": "https://zenodo.org/badge/doi/10.5281/zenodo.6798461.svg", 
    "html": "https://zenodo.org/record/6798462", 
    "latest_html": "https://zenodo.org/record/6798462", 
    "badge": "https://zenodo.org/badge/doi/10.5281/zenodo.6798462.svg", 
    "latest": "https://zenodo.org/api/records/6798462"
  }, 
  "conceptdoi": "10.5281/zenodo.6798461", 
  "created": "2022-07-05T13:19:53.406218+00:00", 
  "updated": "2022-07-05T13:48:41.069844+00:00", 
  "conceptrecid": "6798461", 
  "revision": 2, 
  "id": 6798462, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.6798462", 
    "description": "<p><strong><em>Objective:</em></strong><em> The objective of the paper was to synthesis and characterization of new <em>isoxazole bearing pyrazole derivatives and evaluate them for antibacterial activity.</em></em></p>\n\n<p><strong><em>Material and methods:</em></strong><em> The isoxazole bearing pyrazole derivatives have been synthesized by the utilize the four-step process. Total Ten compounds have been synthesized and characterized by IR, <sup>1</sup>HNMR, elemental and mass spectral analysis. The final compounds (PIA-1 to PIA-10) have been evaluated for antibacterial activity by disk diffusion method using sulfamethoxazole as standard drug.</em></p>\n\n<p><strong><em>Result and Discussion:</em></strong><em> The IR spectra of compound PIA-1 to PIA-10 shown the characteristics peak at 3052 (N-H), 2964 (C-H), 1628 (C=O), 1448 (C=N), 1625 (C=C), 1126 (C-O); 1015 (C-Br); 850 (C-Cl) and 1102 (C-F).&nbsp; The 1HNMR spectrum show the characteristics peak &delta; 6.68-6.70 (d, 2H, Ar-Fluorine), 7.14-7.16 (d, 1H, Ar-chlorine), 7.28-7.30 (m, 5H, Ar-H), 7.58-8.00 (d, 2H, Ar-Chlorine), 7.75-7.78 (d, 2H, Ar-Fluorine), 8.25 (s, 1H, Ar-H isoxazole), 10.97 (s, 1H, -Ar-H pyrazole); 7.26 (s, 1H, Ar-Cl). The antibacterial evaluation of the synthesized compounds stated that Isoxazole-pyrazole derivatives exhibit considerable inhibitory effect on all bacteria strains at both 50 &micro;g/ml and 100 &micro;g/ml dosing levels. PIA-1, PIA-2, PIA-3, PIA-4 had the highest activity in gram positive bacterial stains and PIA-1, PIA-3, PIA-4 and PIA-10 have shown best activity against gram negative bacteria.</em></p>\n\n<p><strong><em>Conclusion</em></strong><em>: The antibacterial activity of the synthesized compounds (PIA-1, PIA-3, PIA-4 and PIA-5) was significantly similar or better than that of standard Drug used for comparison. These Isoxazole bearing pyrazole compounds have demonstrated potency as a superior antibacterial agent, although more in-vivo research on the efficacy and dosage regimen of the compounds is needed.</em></p>\n\n<p><strong>Keywords: </strong><em>Antibacterial activity, Pyrazole, Isoxazole, sulfamethoxazole, disk diffusion</em></p>", 
    "license": {
      "id": "CC-BY-4.0"
    }, 
    "title": "SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NOVEL ISOXAZOLE BEARING PYRAZOLE DERIVATIVES FOR ANTIBACTERIAL ACTIVITY", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "6798461"
          }, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "6798462"
          }
        }
      ]
    }, 
    "publication_date": "2022-07-05", 
    "creators": [
      {
        "name": "Kamlesh Kumar Pandey, Alok Pal Jain, Amit Nayak*"
      }
    ], 
    "access_right": "open", 
    "resource_type": {
      "subtype": "article", 
      "type": "publication", 
      "title": "Journal article"
    }, 
    "related_identifiers": [
      {
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.6798461", 
        "relation": "isVersionOf"
      }
    ]
  }
}
8
8
views
downloads
All versions This version
Views 88
Downloads 88
Data volume 11.9 MB11.9 MB
Unique views 88
Unique downloads 88

Share

Cite as