A REVIEW ON SOURCE, PHYSICOCHEMICAL PROPERTIES, GRADES, PREPARATION, EVALUATION, APPLICATIONS AND PATENTS OF CARBOPOL IN VARIOUS FORMULATIONS

The current review was prepared with the objectives of complying source, grades, properties, preparation, evaluation, applications and patents of carbopol. Carbopol are polyacrylic acid polymers which may be used as bio adhesive vehicles for drug delivery. carbopols crosslinked with ally1 sucrose. Materials are available in a number of grades, depending largely on the molecular weight of the polymer chains. Carbopols are thought to be highly polydisperse, with significant differences in the molecular weight of supposedly identical grades reported. Carbopol is widely used in the pharmaceutical industry due to its high viscosity at low concentrations, good patient acceptability, and low toxicity profile. Initially, they were used as an alternative thickening agent to natural gums. Polyacrylic acid (PAA) is a large-scale commercial polymer that is widely used in a variety of industries, agriculture, and medicine. Controlled release in tablets, bioadhesion in buccal, ophthalmic, intestinal, nasal, vaginal, and rectal applications are all made possible by the readily water swellable carbopol polymers. Thickening at extremely low concentrations to produce a wide range of viscosities and flow properties in topical, lotions, creams, and gels, oral suspensions, and transdermal gel reservoirs. The prepared carbopol were further characterized for yield FTIR, DSC, XRPD, TGA, SEM, Raman Spectroscopy, Charge density and Zeta Potential.

Keywords: Carbopol, sustained release, controlled release, polyacrylic acid,