Antimalarial Agents

ABSTRACT

Malaria is a major public health issue that affects people all around the world. Malaria's name came from the words mal-bad and aria-air. Malaria is a plasmodium infection caused by Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, and Plasmodium malaria, among others. Malaria infection can be treated with a variety of medications. Anemia and fever are both common signs of illness. Malaria has a life cycle. Malaria has an asexual and sexual phase, with the malaria parasite impacting the blood and hepatocytes (liver) of the host. The early stages of the life cycle do not create any symptoms, but fever or chills are developed when merozoites penetrate the host's liver. Because medication resistance is a serious issue for malaria patients, a combination therapy is used to treat malaria patient therefore; combination therapy is used instead of the single drug although it is used to overcome the drug resistance, side effect of drug as well. The focus of this review article is on classification, chemical structure and structural activity relationship of compounds, as well as new discovery and modification. The present article focused on recent development in malaria treatment.

Keywords: Malaria, Life cycle of malaria parasite, Chemistry of Antimalarial agent, structural activity relationship, recent advances in antimalarial agent.