A REVIEW: METHOD DEVELOPMENT AND VALIDATION OF AMLODIPINE AND VALSARTAN.
Description
The key role of the amlodipine drug is, it is the calcium channel blocker. Amlodipine is the drug molecule used to treat the high blood pressure; also, this medication is used for the coronary artery disease. In 1990 amlodipine was approved for its medical use and it was patented in 1982. In comparison with the other class of medications used to lower the blood pressure, amlodipine as a calcium channel blocker is having the greater protection against the stroke. With the variety of the other medication, amlodipine can be used as the combination for treatment. Valsartan is one of the combinations that can be taken along with amlodipine to treat the hypertension where, valsartan is the angiotensin II receptor blocker. Along with the high pressure and heart failure, valsartan is the medication that can be used to treat diabetic kidney disease. For analyzing this combination qualitatively and quantitatively, analytical techniques were found to be effective. Various research articles, literature papers were collected and reviewed reporting the analytical techniques mostly by HPLC and spectrophotometric for amlodipine and losartan and their combination. Review articles will find to be advantageous for developing an accurate and precise analytical method and for their validation studies.
Keywords: QBD approach, Amlodipine, Valsartan, RP-HPLC, method development and validation
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