SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES OF SUBSTITUTED 2-AMINO 3-CHLORO NAPHTHOQUINONE DERIVATIVES
Description
The present work deals with designing of some novel substituted 2 -amino 3- chloro naphthalene – 1,4 dione derivatives on the basis reaction between 2,3- dichloronaphthalene -1,4-dione and various secondary amine like 5-amino uracil (L1), 5-amino 1,3-dimethyl uracil (L2), 2-amino-chromen (L3), 2-amino- furan (L4) and isonicotinohydrazide (L5) in presence of ethanol. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, Mass spectrometry and elementary analysis. Preliminary QSAR study was carried out for the synthesized compounds. All the compounds obeyed the Lipnski rule of 5. Solubility characters of synthesized compounds were carried out by using various solvents. The tested compounds are freely soluble in DMSO, soluble in chloroform and methanol, slightly soluble in acetone, ethyl acetate and ethanol and insoluble in water. The structures of the synthesized compounds were studied using Autodock software against Topoisomerease II as a target enzymes. The docking results showed that Compounds L3, L2, L4, and L1 were found to have significant binding score against target enzyme Topoisomerase compared to standard drug Etaposide.
Keywords: Molecular Docking, Naphthoquinone, Synthesis, Characterization
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37.Chem manuscript.pdf
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