Published June 16, 2022
| Version v1
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SIROLIMUS IN TABLET
- 1. Dept of Pharmaceutical Quality Assurance, D.S.T.S. Mandal's College of Pharmacy, Solapur.
Description
Sirolimus is a macrolide compound used to prevent organ transplant rejection. A UV spectrophotometric method has been developed for the estimation of sirolimus in the tablet. Ethanol is used as a solvent. Sirolimus has shown absorbance maxima at 278 nm. The method was validated according to ICH Q2 (R1) guidelines. The method is linear in the range of 5-30 μg/ml and exhibited a good correlation coefficient (R2=0.9992) with a recovery of 98-100% and precision. The developed analytical method is simple, accurate, precise, and can be applied for routine analysis of formulation containing Sirolimus in a short time.
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