FORMULATION DEVELOPMENT AND EVALUATION OF OCULAR IN SITU GEL OF NSAIDS DRUG FOR EFFECTIVE TREATMENT OF EYE DISEASE

Ophthalmic in situ gelling system of Suprofen was successfully formulated using polymeric combination of gelling agents Sodium Alginate, HPMC E 50 LV, HPMC K4 M as viscosity enhancing agent. All the formulations except F7, F8 and F9 showed instantaneous gelation when contacted with simulated tear fluid (STF), formulation F6 showed best gelation property amongst all other. The In vitro drug release data of the optimized formulation was subjected to goodness of fit test by linear regression analysis according to zero order, first order Higuchi and Korsmeyer peppas release kinetic equation in order to determine the mechanism of drug release. When the regression coefficient values of were compared, it was observed that ‘r’ values of first order was maximum hence indicating drug release from formulations was found to follow Korsmeyer peppas release kinetics.  Evaluation of in situ gel is determined to ensure that the prepared preparation meets the standard and is safe. In the chemical evaluation in situ gel determined the diffusion of the active substance of a compound by measuring its concentration.

Hey words: Suprofen, Sodium Alginate, HPMC E 50 LV, HPMC K4 M