A SCHEMATIC APPROACH OF EMULSIFYING AGENT AND PERMEATION ENHANCER IN CREAM.

Topical route of application has a great potential as an effective and safe way to administer drug for its antifungal in effect. The concentration of surfactant and permeation enhancer significantly affects the critical parameters of cream formulation like flux, cumulative amount released at 12 hours and Enhancement ratio. In vitro permeation study across rat epidermal membrane showed that menthol enhanced the transdermal absorption of drug from cream formulation. The topical cream formulation developed in this study holds the promise for the further in vivo studies.

The aim of the present work under investigation is to check the effects of emulsifying agents(Cremophore RH40, Tween 60) and permeation enhancers (l-Menthol) on cream.  Developing a formulation that is safe and can deliver the drug locally in an effective concentration for its effect . The development of topical antifungal drug delivery systems designed to have localised effects appears to be very advisable and beneficial over conventional routes of drug administration.  However, due to the relative impermeability of the stratum corneum, which} provides the principal resistance to percutaneous absorption, extensive studies are generally necessary in order to optimize both the release of the drug from the topical vehicle and skin permeation Further, A topical formulation must be aesthetically pleasing, in addition to being} both physically and chemically stable, this require numerous excipients.  Emulsifying agents and permeation enhancers have major influence on these} properties, hence they play an important role.

Key words: of emulsifying agents, Permeation enhancers, stratum corneum, Antifungal , Topical cream