PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT BETA VULGARIS L. LEAVES

Gastroesophageal reflux disease, gastritis, peptic ulcer, duodenal ulcer, and other peptic illnesses are frequent in today's lifestyle. This could be the result of a hectic lifestyle or an unbalanced diet. The pathophysiology underlying these illnesses could be a mismatch between offensive and defensive mechanisms, either due to excessive acid and pepsin secretion or a decreased ability of the gastro-duodenal mucosal barrier to guard against acid-pepsin secretion from the stomach. Non-steroidal anti-inflammatory drugs (NSAIDs) are a type of therapy that has been shown to be beneficial in treating a variety of ailments. Some people take NSAIDs on a daily basis to keep themselves healthy. NSAIDs, on the other hand, can cause a wide range of serious adverse effects. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. As a result, the purpose of this study was to assess the antiulcer activity of an ethanolic extract of Beta vulgaris leaves in rats. The well-known test technique in the literature was used to determine the qualitative analysis of several phytochemical elements. The anti-ulcer efficacy of ethanolic extract was tested in vivo. The pH of stomach fluid, ulcer index, and percent inhibition of ulcer index were used as outcome measures, depending on the model. Because of one or more of the secondary metabolites included in Beta vulgaris extract, the results of this investigation indicated that it possesses anti-ulcer pharmacologic efficacy. As a result, this research backs up its anti-ulcer use in Indian folk medicine. More research is needed into isolating particular phytochemicals and understanding mechanisms of action.

Keywords:Beta vulgaris, Phytochemical constituents, Antiulcer, Non-steroidal anti-inflammatory drugs