DEVELOPMENT AND IN-VITRO EVALUATION OF IN SITU GELS OF HYDROCORTISONE FROM TEMPERATURE INDUCED GELLING SYSTEM.

Aphthous ulcers are painful sores that may occur in the mouth's mucous membrane and are the most common type of oral lesions. The present work was aimed to develop a in-situ gels and films of hydrocortisone for the treatment of aphthous ulcer. The in-situ gels and film was developed by using methylcellulose, based on the concept of temperature dependent gelling system. The sol-to-gel transformation occurred during the reduction of temperature. The in-situ gels were evaluated for gelling capacity, drug content, viscosity & in-vitro release were as in the film its evaluated for tensile strength, folding endurance, thickness etc. The experimental part shows that viscosity of the sol was increased by increasing the concentration of polymer. All the results were found to be satisfactory, when compared between the in-situ gels and films. The has shown the best formulation because of their therapeutic efficacy and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional drug delivery system, patient compliance, industrially oriented and economical.

Key words: In situ, Film, Methylcellulose, Gellation temperature & gellation time.