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Published June 2, 2022 | Version v1
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OVERVIEW OF CLINICAL RESEARCH AND ITS APPLICATIONS IN DRUG DISCOVERY AND MANAGEMENT OF COVID-19 IN INDIA

Description

COVID-19 is a disease caused by SARS-CoV-2 that can trigger what scientists call a respiratory tract infection. It can affect your upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract ( lungs and windpipe). The clinical demonstration of SARS-CoV-2-infected patients ranged from mild non-specific symptoms to severe pneumonia with organ function destruction. In December 2019, adults in Wuhan, capital city of Hubei province and a major transportation hub of China started presenting to local hospitals with severe pneumonia of unknown cause. Research on COVID-19 from Alternative and Complementary Medicines are being carried out in many countries. In Ayurveda, the majority of the trials are related to ayurvedic drugs or drug combinations.  The recommended formulations, some have undergone scientific investigations, such as AYUSH, Arsenica Album, Chyawanprash, Kabasur Kudineer, Guduchi, Ghanavati, Nilavembu Kudineer, for their possible preventive or therapeutic impact. One of the potential treatment strategies is the discovery of drugs by targeting essential proteins in viral life cycle. Main Protease become an attractive drug target, since it plays a pivotal role in mediating viral transcription and replication. According to the data published by FDA’s Coronavirus Treatment Acceleration Program (CTAP), as on 31 December 2020 there were 595+ drug development programs in planning stages, 400+ trials reviewed by FDA, 8 treatments currently authorised for emergency use and 1 treatment approved for COVID 19.

KEYWORDS: COVID-19, SARS-CoV-2, Clinical research, AYUSH, Drug discovery process

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