DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF DEXRABEPRAZOLE FOR EFFECTIVE TREATMENT OF GASTRIC ULCER

Absorption of drugs with a limited absorption window in the gastrointestinal tract (GIT) is low. Gastroretentive drug delivery methods provide the advantage of delaying stomach emptying time for these medicines. The goal of developing floating Dexrabeprazole tablets was to extend the stomach residence period following oral treatment in order to achieve regulated medication release. Dexrabeprazole floating tablets were made by direct compression with different grades of Hydroxyl Propyl Methyl Cellulose (HPMC) and PVP K30 utilising an effervescent process. As a gas-generating agent, sodium bicarbonate was used.  Citric acid's effect on medication release profile and floating qualities was also examined. The preformulation parameters were within the limits of the pharmacopoeias. Weight uniformity, content uniformity, thickness, hardness, in vitro release experiments, buoyancy determination, and kinetic analysis of dissolving data were all used to evaluate tablets. The tablet had a 1-minute lag time and remained buoyant for 12 hours. The in-vitro drug release pattern of improved ciprofloxacin floating tablets (F8) was fitted to various kinetic models, with Higuchi order release kinetics showing the best fit (r2 = 0.984). Ciprofloxacin floating tablets had a longer gastrointestinal residence period, which improved the drug's bioavailability and therapeutic impact.

Keywords: Dexrabeprazole, Floating drug delivery system, Hydroxy propyl methyl cellulose,

Direct compression method, Buoyancy determination.