DEVELOPMENT AND CHARACTERIZATION OF NOVEL CARRIER FOR DRUG DELIVERY OF ANTIFUNGAL DRUG

Fungal infections are the most common diseases found in tropical countries like India, but these infections are neglected and hence spread to other parts of the body. The most commonly used antifungal agents are Miconazole, these molecules being imidazole derivatives with high lipophilicity. It act against most pathogenic fungi and some Gram- positive bacteria. Usually, they are well tolerated and their low toxicity allows them to be safely used for treating several cutaneous or systemic infections. Encouraging results have been obtained on the treatment of topical fungal infections with liposomal or novel vesicular formulations of these antifungal drugs, but due to their size and rigid lipid bilayer they were not able to penetrate efficiently across the skin layer. The transfersome preparations containing Miconazole are conceptually sophisticated; they are characterized by simplicity in their preparation, good stability, safety and efficacy that can highly expand their application in the treatment of fungal infections.

Keywords: Fungal infection, Miconazole, Transfersome ,Drug delivery system, Antifungal drugs.