MODIFIED RELEASE HYDROGELS OF IBUPROFEN FOR ORAL DRUG DELIVERY: AN OVERVIEW
Description
The Present study for hydrogels are specifically on the pH sensitive hydrogels for oral drug delivery system. Hydrogels are able to improve oral delivery of several therapeutic agents established by various in-vitro methodologies.
Hydrogels are basically cross-linked polymers with hydrophilic nature & consist of acidic, basic, or neutral monomers which are able to swallow large amounts of water. Due to hydrophilic nature of polymer chains, hydrogels will engross water to swell in the presence of abundant water. The swelling properties of hydrogels are due to elasticity of the network, presence of hydrophilic functional groups (such as -COOH,-OH, -SO3H,-CONH2) in the polymer chains. The physiochemical properties, swelling studies and gelling capacity significantly govern the selection of hydrogel component.
The development of hydrogels has received substantial consideration over past few years. This interest has been flickered by the advantages these advanced delivery system possess, which include modified, sustained and prolonged action, reduced dose, less side-effects, better drug utilization, better patient compliance, site specific drug targeting, protection of mucosa from irritation, prevention from general first pass metabolism .Non-steroidal anti-inflammatory drugs are mostly prescribed for the patients suffering from rheumatoid arthritis, osteoarthritis, soft tissue injuries, traumatic arthritis and other inflammatory disorders etc.
Ibuprofen is non-steroidal anti-inflammatory drug (NSAID) which is anti-inflammatory, antipyretic and analgesic properties. It is chemically "2-(4-iso-butylphenyl) - propanoic acid" and is poorly soluble in water. It is mostly administered through oral route and is rapidly absorbed to reach its maximal plasma concentration within 2 hrs. It has a short biological half-life period of 2 hours, which means that numerous doses are required to maintain the therapeutic efficacy level over extended period of time. Frequent administrations of drug cause GIT side effects such as gastric ulceration, perforation and bleeding.
pH sensitive hydrogel of ibuprofen attain a more modified & sustain release of the drug for long periods of time interval. Hence we can minimize the required dose and toxicity of the drug.
Keywords: Hydrogels, Polymer, NSAID, Ibuprofen & pH sensitive.
Files
2.ANU A L-anu 111 (1).pdf
Files
(1.0 MB)
Name | Size | Download all |
---|---|---|
md5:f4f96c1aa5952c0919a0259df4a2f7f2
|
1.0 MB | Preview Download |