EVALUATION OF ANTI-HYPERTENSIVE DRUG PRESCRIPTION PATTERN ACCORDING TO JOINT NATIONAL COMMITTEE-8, ASSESSMENT OF MEDICATION ADHERENCE AND DRUG RELATED PROBLEM IN TYPE-2 DIABETES MELLITUS PATIENTS

The aim of the study is evaluation of anti-hypertensive drug prescription pattern according to Joint National Committee-8, assessment of medication adherence and drug related problem in type-2 diabetes mellitus patients. The objectives of the study is to evaluate the prescribing pattern of anti-hypertensive drugs in type 2 diabetic patients according to JNC-8 guidelines, to assess medication adherence to treatment, to assess major drug-drug interactions, and to assess drug inappropriateness. A prospective and hospital based study was conducted on in-patients admitted in a tertiary care teaching hospital. Data regarding patient’s demographic details, diagnosis, complete prescription, and any other information will be collected in a predesigned pro forma. The study reveals that males (58%) were more likely to have reported with hypertension and diabetes. Among all medications the major class of drugs prescribed were calcium channel blockers (44.48%) and diuretics (32.65%). The most common anti-hypertensive drugs prescribed were amlodipine (43.67%), Lasix (27.75%). Out of 339 drug-drug interactions, 53(4.61%) were major, 906 (78.85%) were moderate and 190(16.53%) were minor. Morisky medication adherence scale analysis showed fair adherence to the treatment. The present study concluded that the prescribing pattern of antihypertensive drugs showed less adherence to current JNC-8 guideline. However, further studies are needed to identify the rationale in the prescribing pattern. The study also tried to depict the drug related problems in the patients. Hence, the study reveals a lot of potential for pharmaceutical care services and the relevance of having clinical pharmacist on the wards to access patients drug- related needs.