EVALUATION OF IN-VITRO ANTIHELMINTHIC POTENCY OF ETHANOLIC EXTRACT OF TEPHROSIA PURPUREA

Various species of genus Tephrosia have been extensively studied for their pharmacological activity. Tephrosia purpurea is expected to possess many constituents among them triterpenoids are major constituents. So due to presence of triterpenoids Tephrosia purpurea may possess Antihelmintic activity. In the present work ethanolic extract of leaves of Tephrosia purpurea was evaluated for its Anthelmintics activity against earthworm at three different concentrations (25, 50, 100 mg/ml). The Antihelmintic activity of extract was comparable with Marketed allopathic drugs (Piperazine citrate (10 mg/ml), Albendazole (25 mg/ml, 50 mg/ml), Ivermectin (5 mg/ml), Levamisole (10 mg/ml). 2% v/v Tween 80 in water was taken as a normal control. Marketed allopathic drugs concentrations were prepared using 2% v/v Tween 80. Antihelmintic activity was evaluated by considering the time required for mobility, paralysis and death of worms by all the prepared extracts and marketed allopathic drugs concentrations.

 Levamisole>Piperazine citrate>Tephrosia purpurea leaf extract>Ivermectin>Albendazole.

Key Words: Tephrosia purpurea, Antihelmintic activity, Earthworms.