FORMULATION AND IN-VITRO EVALUATION OF ULTRA-DEFORMABLE VESICULAR GEL OF ETODOLAC

Transferosome is an ultra-deformable, highly flexible and stress-responsive complex system which consists of aqueous core surrounded composite lipid bilayer. Due to their resizing and self- optimized property, they are able to deliver low as well as high molecular weight into or through the skin. The main objective of this study is to prepare etodolac loaded transfersomes for the treatment of osteoarthritis. The dispersion of Etodolac loaded transfersomes was prepared by changing the ratio of surfactant and phospholipid by thin film hydration method. Prepared transferosme of Etodolac was optimized on the basis of various in-vitro evaluation characteristics such as zeta potential, TEM, etc.  Optimized transferosome were further converted to Gel by using various concentrations of containing Carbopol 934. All gel formulations were evaluated for spreadability, extrudability, viscosity, pH, in vitro diffusion, stability study and found good results. From the % drug release kinetics study it was concluded that formulation follows zero order kinetics.

Keywords: Transfersomes, Gel, Etodolac, Zeta potential, TEM, Entrapment efficiency.