FORMULATION OF DEXTROMETHORPHAN HYDROBROMIDE EXTENDED-RELEASE SUSPENSION AND EVALUATION
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Description
Dextromethorphan hydrobromide is a synthetic anti tussive agents. Biological half-life of this drug is 2-4hrs. Due to its half-life, the dose is employed 4times a day. To reduce the dose frequency and to improve the patient compliance, the extended-release suspension of dextromethorphan polistirex was formulated with PEG coating and Enteric coating. In the present study the extended-release suspension of dextromethorphan polistirex was prepared and physical mixture of the drug and polymer was found to be compatible after the comparative study of three months. The extended-release suspension of dextromethorphan polistirex was evaluated by FTIR, DSC and other parameters. Difference factor (f2) was used as a statistical method in this work.The formulation showed advantages in the terms of patient compliance, safety, and better transportation over existing suspension formulation.
Key words: Dextromethorphan polistirex, Surelease Dispersion, Delsym.
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31.JHANCY PAV PUB.pdf
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