EXTRACTION, PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC & ANTIPYRETIC ACTIVITY OF HYDROALCOHOLIC LEAF EXTRACT OF SOLENUM VIRGINIANUM

Solanum virginianum used by the local people as folk medicines in treating throat infections and other inflammatory problems. The fruits are known for several medicinal uses like anthelmintic, antipyretic, laxative, anti-inflammatory, anti-asthmatic and aphrodisiac activities. The fruit paste is applied externally to the affected area for treating pimples and swellings. The various parts of the plant are reputed in indigenous Hindu Medicine to have high medicinal value in various diseases like cough, asthma, fever, heart disease etc. This study was designed to evaluate different in vitro biological activities like antioxidant activity, antimicrobial activity and in vivo anti-pyretic and analgesic activities of hydroalcoholic extract of leaves of Solanum virginianum The effect of hydroalcoholic extract of leaves of Solanum virginianum were determined after administration at two dose levels (100 and 200 mg/kg b.w.) in yeast induced pyrexia and tail immersion in rats. Our findings suggest a medicinal plant with multiple therapeutic properties that could serve as an antipyretic drug. To elucidate the exact mechanism of action of these active constituents, further investigation is required.

Key words: Solanum virginianum, Hydroalcoholic extract, Analgesic, Antipyretic Activity