Journal article Open Access

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.

Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen


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    <subfield code="a">&lt;p&gt;While no definitive cure for Alzheimer&amp;#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &amp;beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &amp;beta; (A&amp;beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&amp;nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&amp;nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&amp;nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&amp;nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&amp;beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&amp;beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.&lt;/p&gt;</subfield>
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