Journal article Open Access
Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Magnetic resonance imaging</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Magnetization transfer contrast imaging</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Alzheimer's disease</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">White matter</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">APP/PS1</subfield> </datafield> <controlfield tag="005">20200120141011.0</controlfield> <controlfield tag="001">60360</controlfield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Bigot, Christian</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Orije, Jasmien</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Naeyaert, Maarten</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Shah, Disha</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Mai, Zhenhua</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Guns, Pieter-Jan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Van der Linden, Annemie</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Verhoye, Marleen</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="s">4217064</subfield> <subfield code="z">md5:2bffd7d0ff6e39b65cb3f74d0ebafb7d</subfield> <subfield code="u">https://zenodo.org/record/60360/files/Praet_NeuroImageClin_2016-P7.pdf</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2016-06-16</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="p">openaire</subfield> <subfield code="p">user-ecfunded</subfield> <subfield code="p">user-inmind</subfield> <subfield code="o">oai:zenodo.org:60360</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="c">85-92</subfield> <subfield code="v">12</subfield> <subfield code="p">Neuroimage Clinical</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</subfield> <subfield code="a">Praet, Jelle</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-ecfunded</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-inmind</subfield> </datafield> <datafield tag="536" ind1=" " ind2=" "> <subfield code="c">278850</subfield> <subfield code="a">Imaging of Neuroinflammation in Neurodegenerative Diseases</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield> <subfield code="a">Creative Commons Attribution 4.0 International</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>While no definitive cure for Alzheimer&#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &beta; (A&beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.</p></subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.nicl.2016.06.014</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> </record>
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