Journal article Open Access

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.

Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen


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{
  "description": "<p>While no definitive cure for Alzheimer&#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &beta; (A&beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.</p>", 
  "license": "http://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Praet, Jelle"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Bigot, Christian"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Orije, Jasmien"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Naeyaert, Maarten"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Shah, Disha"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Mai, Zhenhua"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Guns, Pieter-Jan"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Van der Linden, Annemie"
    }, 
    {
      "affiliation": "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium", 
      "@type": "Person", 
      "name": "Verhoye, Marleen"
    }
  ], 
  "headline": "Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2016-06-16", 
  "url": "https://zenodo.org/record/60360", 
  "keywords": [
    "Magnetic resonance imaging", 
    "Magnetization transfer contrast imaging", 
    "Alzheimer's disease", 
    "White matter", 
    "APP/PS1"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1016/j.nicl.2016.06.014", 
  "@id": "https://doi.org/10.1016/j.nicl.2016.06.014", 
  "@type": "ScholarlyArticle", 
  "name": "Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model."
}