Journal article Open Access
Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://zenodo.org/record/60360</identifier> <creators> <creator> <creatorName>Praet, Jelle</creatorName> <givenName>Jelle</givenName> <familyName>Praet</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Bigot, Christian</creatorName> <givenName>Christian</givenName> <familyName>Bigot</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Orije, Jasmien</creatorName> <givenName>Jasmien</givenName> <familyName>Orije</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Naeyaert, Maarten</creatorName> <givenName>Maarten</givenName> <familyName>Naeyaert</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Shah, Disha</creatorName> <givenName>Disha</givenName> <familyName>Shah</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Mai, Zhenhua</creatorName> <givenName>Zhenhua</givenName> <familyName>Mai</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Guns, Pieter-Jan</creatorName> <givenName>Pieter-Jan</givenName> <familyName>Guns</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Van der Linden, Annemie</creatorName> <givenName>Annemie</givenName> <familyName>Van der Linden</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> <creator> <creatorName>Verhoye, Marleen</creatorName> <givenName>Marleen</givenName> <familyName>Verhoye</familyName> <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation> </creator> </creators> <titles> <title>Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.</title> </titles> <publisher>Zenodo</publisher> <publicationYear>2016</publicationYear> <subjects> <subject>Magnetic resonance imaging</subject> <subject>Magnetization transfer contrast imaging</subject> <subject>Alzheimer's disease</subject> <subject>White matter</subject> <subject>APP/PS1</subject> </subjects> <dates> <date dateType="Issued">2016-06-16</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/60360</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.nicl.2016.06.014</relatedIdentifier> <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier> <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract"><p>While no definitive cure for Alzheimer&#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &beta; (A&beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.</p></description> </descriptions> <fundingReferences> <fundingReference> <funderName>European Commission</funderName> <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier> <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber> <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle> </fundingReference> </fundingReferences> </resource>
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