Journal article Open Access

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.

Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen


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  <identifier identifierType="URL">https://zenodo.org/record/60360</identifier>
  <creators>
    <creator>
      <creatorName>Praet, Jelle</creatorName>
      <givenName>Jelle</givenName>
      <familyName>Praet</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Bigot, Christian</creatorName>
      <givenName>Christian</givenName>
      <familyName>Bigot</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Orije, Jasmien</creatorName>
      <givenName>Jasmien</givenName>
      <familyName>Orije</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Naeyaert, Maarten</creatorName>
      <givenName>Maarten</givenName>
      <familyName>Naeyaert</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Shah, Disha</creatorName>
      <givenName>Disha</givenName>
      <familyName>Shah</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Mai, Zhenhua</creatorName>
      <givenName>Zhenhua</givenName>
      <familyName>Mai</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Guns, Pieter-Jan</creatorName>
      <givenName>Pieter-Jan</givenName>
      <familyName>Guns</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Van der Linden, Annemie</creatorName>
      <givenName>Annemie</givenName>
      <familyName>Van der Linden</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
    <creator>
      <creatorName>Verhoye, Marleen</creatorName>
      <givenName>Marleen</givenName>
      <familyName>Verhoye</familyName>
      <affiliation>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2016</publicationYear>
  <subjects>
    <subject>Magnetic resonance imaging</subject>
    <subject>Magnetization transfer contrast imaging</subject>
    <subject>Alzheimer's disease</subject>
    <subject>White matter</subject>
    <subject>APP/PS1</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2016-06-16</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/60360</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.nicl.2016.06.014</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;While no definitive cure for Alzheimer&amp;#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &amp;beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &amp;beta; (A&amp;beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&amp;nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&amp;nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&amp;nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&amp;nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&amp;beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&amp;beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
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