Journal article Open Access
Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen
<?xml version='1.0' encoding='utf-8'?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#"> <rdf:Description rdf:about="https://zenodo.org/record/60360"> <rdf:type rdf:resource="http://www.w3.org/ns/dcat#Dataset"/> <dct:type rdf:resource="http://purl.org/dc/dcmitype/Text"/> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/60360</dct:identifier> <foaf:page rdf:resource="https://zenodo.org/record/60360"/> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Praet, Jelle</foaf:name> <foaf:givenName>Jelle</foaf:givenName> <foaf:familyName>Praet</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Bigot, Christian</foaf:name> <foaf:givenName>Christian</foaf:givenName> <foaf:familyName>Bigot</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Orije, Jasmien</foaf:name> <foaf:givenName>Jasmien</foaf:givenName> <foaf:familyName>Orije</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Naeyaert, Maarten</foaf:name> <foaf:givenName>Maarten</foaf:givenName> <foaf:familyName>Naeyaert</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Shah, Disha</foaf:name> <foaf:givenName>Disha</foaf:givenName> <foaf:familyName>Shah</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Mai, Zhenhua</foaf:name> <foaf:givenName>Zhenhua</foaf:givenName> <foaf:familyName>Mai</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Guns, Pieter-Jan</foaf:name> <foaf:givenName>Pieter-Jan</foaf:givenName> <foaf:familyName>Guns</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Van der Linden, Annemie</foaf:name> <foaf:givenName>Annemie</foaf:givenName> <foaf:familyName>Van der Linden</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Verhoye, Marleen</foaf:name> <foaf:givenName>Marleen</foaf:givenName> <foaf:familyName>Verhoye</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:title>Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.</dct:title> <dct:publisher> <foaf:Agent> <foaf:name>Zenodo</foaf:name> </foaf:Agent> </dct:publisher> <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2016</dct:issued> <dcat:keyword>Magnetic resonance imaging</dcat:keyword> <dcat:keyword>Magnetization transfer contrast imaging</dcat:keyword> <dcat:keyword>Alzheimer's disease</dcat:keyword> <dcat:keyword>White matter</dcat:keyword> <dcat:keyword>APP/PS1</dcat:keyword> <frapo:isFundedBy rdf:resource="info:eu-repo/grantAgreement/EC/FP7/278850/"/> <schema:funder> <foaf:Organization> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier> <foaf:name>European Commission</foaf:name> </foaf:Organization> </schema:funder> <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2016-06-16</dct:issued> <owl:sameAs rdf:resource="https://zenodo.org/record/60360"/> <adms:identifier> <adms:Identifier> <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/60360</skos:notation> <adms:schemeAgency>url</adms:schemeAgency> </adms:Identifier> </adms:identifier> <owl:sameAs rdf:resource="https://doi.org/10.1016/j.nicl.2016.06.014"/> <dct:isPartOf rdf:resource="https://zenodo.org/communities/ecfunded"/> <dct:isPartOf rdf:resource="https://zenodo.org/communities/inmind"/> <dct:description><p>While no definitive cure for Alzheimer&#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &beta; (A&beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.</p></dct:description> <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/> <dct:accessRights> <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess"> <rdfs:label>Open Access</rdfs:label> </dct:RightsStatement> </dct:accessRights> <dcat:distribution> <dcat:Distribution> <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/> <dcat:accessURL rdf:resource="https://zenodo.org/record/60360"/> </dcat:Distribution> </dcat:distribution> <dcat:distribution> <dcat:Distribution> <dcat:accessURL>https://doi.org/10.1016/j.nicl.2016.06.014</dcat:accessURL> <dcat:byteSize>4217064</dcat:byteSize> <dcat:downloadURL>https://zenodo.org/record/60360/files/Praet_NeuroImageClin_2016-P7.pdf</dcat:downloadURL> <dcat:mediaType>application/pdf</dcat:mediaType> </dcat:Distribution> </dcat:distribution> </rdf:Description> <foaf:Project rdf:about="info:eu-repo/grantAgreement/EC/FP7/278850/"> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">278850</dct:identifier> <dct:title>Imaging of Neuroinflammation in Neurodegenerative Diseases</dct:title> <frapo:isAwardedBy> <foaf:Organization> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier> <foaf:name>European Commission</foaf:name> </foaf:Organization> </frapo:isAwardedBy> </foaf:Project> </rdf:RDF>
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