Journal article Open Access

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.

Praet, Jelle; Bigot, Christian; Orije, Jasmien; Naeyaert, Maarten; Shah, Disha; Mai, Zhenhua; Guns, Pieter-Jan; Van der Linden, Annemie; Verhoye, Marleen


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{
  "DOI": "10.1016/j.nicl.2016.06.014", 
  "container_title": "Neuroimage Clinical", 
  "title": "Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model.", 
  "issued": {
    "date-parts": [
      [
        2016, 
        6, 
        16
      ]
    ]
  }, 
  "abstract": "<p>While no definitive cure for Alzheimer&#39;s disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC) imaging is able to detect amyloid &beta; plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid &beta; (A&beta;) induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT) and APP/PS1 mice at 2, 4, 6, 8 and 24&nbsp;months of age. We observed an increased MT-ratio in the cortex of 24&nbsp;month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8&nbsp;months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8&nbsp;month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the A&beta; plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early A&beta;-induced changes in the splenium but not the cortex of APP/PS1 mice.</p>", 
  "author": [
    {
      "family": "Praet, Jelle"
    }, 
    {
      "family": "Bigot, Christian"
    }, 
    {
      "family": "Orije, Jasmien"
    }, 
    {
      "family": "Naeyaert, Maarten"
    }, 
    {
      "family": "Shah, Disha"
    }, 
    {
      "family": "Mai, Zhenhua"
    }, 
    {
      "family": "Guns, Pieter-Jan"
    }, 
    {
      "family": "Van der Linden, Annemie"
    }, 
    {
      "family": "Verhoye, Marleen"
    }
  ], 
  "page": "85-92", 
  "volume": "12", 
  "type": "article-journal", 
  "id": "60360"
}