10.2967/jnumed.116.173013
https://zenodo.org/records/59523
oai:zenodo.org:59523
Golla, Sandeep SV
Sandeep SV
Golla
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Boellaard, Ronald
Ronald
Boellaard
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Oikonen, Vesa
Vesa
Oikonen
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Hoffmann, Anja
Anja
Hoffmann
Bayer HealthCare AG, Berlin, Germany
van Berckel, Bart NM
Bart NM
van Berckel
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Windhorst, Albert D
Albert D
Windhorst
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Virta, Jere
Jere
Virta
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
te Beek, Eric T
Eric T
te Beek
Center for Human Drug Research, Leiden, The Netherlands
Groeneveld, Geert Jan
Geert Jan
Groeneveld
Center for Human Drug Research, Leiden, The Netherlands
Haaparanta-Solin, Merja
Merja
Haaparanta-Solin
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Luoto, Pauliina
Pauliina
Luoto
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Savisto, Nina
Nina
Savisto
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Solin, Olof
Olof
Solin
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Valencia, Ray
Ray
Valencia
Bayer HealthCare AG, Berlin, Germany
Thiele, Andrea
Andrea
Thiele
Bayer HealthCare AG, Berlin, Germany
Eriksson, Jonas
Jonas
Eriksson
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Schuit, Robert C
Robert C
Schuit
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Lammertsma, Adriaan A
Adriaan A
Lammertsma
Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Rinne, Juha O
Juha O
Rinne
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
Parametric binding images of the TSPO ligand [18F]DPA-714.
Zenodo
2016
Molecular Imaging
Neurology
PET
PET/CT
Parametric images
Radiotracer Tissue Kinetics;
TSPO
[18F]DPA-714
2016-06-03
https://zenodo.org/communities/inmind
https://zenodo.org/communities/eu
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide (18F-DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of 18F-DPA-714 binding.
METHODS: Ninety minutes dynamic 18F-DPA-714 positron emission tomography scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer's disease (AD) patients were used. Plasma input based Logan graphical and spectral (SA) analyses were used to generate parametric volume of distribution (VT) images. Five versions of Ichise, reference Logan (RLogan) and two basis function implementations (Receptor Parametric Mapping, RPM; Simplified Reference Tissue Model2, SRTM2) of SRTM, all using grey matter cerebellum as reference region, were used to generate binding potential (BPND) images.
RESULTS: Plasma input Logan (r2 = 0.99, slope = 0.88) and SA (r2 = 0.99, slope = 0.93) generated estimates of VT that correlated well with values obtained using non-linear regression. BPND values generated using SRTM2 (r2 = 0.83, slope = 0.95) and RLogan (r2 = 0.88, slope = 1.01) correlated well with non-linear regression based estimates.
CONCLUSION: Both Logan and SA can be used to obtain quantitatively accurate VT images of 18F-DPA-714. In addition, SRTM2 and RLogan can provide accurate BPND images. These parametric images could be used for voxel based comparisons.
European Commission
10.13039/501100000780
278850
Imaging of Neuroinflammation in Neurodegenerative Diseases