Journal article Open Access

Design of Infusion Schemes for Neuroreceptor Imaging: Application to [(11)C]Flumazenil-PET Steady-State Study.

Feng, Ling; Svarer, Claus; Madsen, Karine; Ziebell, Morten; Dyssegaard, Agnete; Ettrup, Anders; Hansen, Hanne Demant; Lehel, Szabolcs; Yndgaard, Stig; Paulson, Olaf Bjarne; Knudsen, Gitte Moos; Pinborg, Lars Hageman


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    "doi": "10.1155/2016/9132840", 
    "description": "<p>This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly. Tracer kinetics was determined from bolus studies and used to construct the system. Subsequently, the system was used to design inputs for bolus infusion (BI) or programmed infusion (PI) experiments. Steady-state quantitative measurements can be made with one short scan and venous blood samples. The GABAA receptor ligand [(11)C]Flumazenil (FMZ) was chosen for this purpose, as it lacks a suitable reference region. Methods. Five bolus [(11)C]FMZ-PET scans were conducted, based on which population-based PI and BI schemes were designed and tested in five additional healthy subjects. The design of a PI was assisted by an offline feedback controller. Results. The system could reproduce the measurements in blood and brain. With PI, [(11)C]FMZ steady state was attained within 40 min, which was 8 min earlier than the optimal BI (B/I ratio = 55 min). Conclusions. The system can design both BI and PI schemes to attain steady state rapidly. For example, subjects can be [(11)C]FMZ-PET scanned after 40 min of tracer infusion for 40 min with venous sampling and a straight-forward quantification. This simulation toolbox is available for other PET-tracers.</p>", 
    "license": {
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    "title": "Design of Infusion Schemes for Neuroreceptor Imaging: Application to [(11)C]Flumazenil-PET Steady-State Study.", 
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      "volume": "2016", 
      "pages": "9132840", 
      "title": "Biomed Research International"
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        "title": "Imaging of Neuroinflammation in Neurodegenerative Diseases", 
        "acronym": "INMIND", 
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    "publication_date": "2016-03-31", 
    "creators": [
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Feng, Ling"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Svarer, Claus"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Madsen, Karine"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Ziebell, Morten"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Dyssegaard, Agnete"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Ettrup, Anders"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Hansen, Hanne Demant"
      }, 
      {
        "affiliation": "PET and Cyclotron Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Lehel, Szabolcs"
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      {
        "affiliation": "Heart Centre, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark", 
        "name": "Yndgaard, Stig"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark; Faculty of Health and Medicine Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen, Denmark and Danish Research Centre Magnetic Resonance, Copenhagen University Hospital, Hvidovre Hospital, Kettegaard All\u00b4e 30, 2650Hvidovre, Denmark", 
        "name": "Paulson, Olaf Bjarne"
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      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark and Faculty of Health and Medicine Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen, Denmark", 
        "name": "Knudsen, Gitte Moos"
      }, 
      {
        "affiliation": "Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark; Faculty of Health and Medicine Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen, Denmark and Epilepsy Clinic, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark", 
        "name": "Pinborg, Lars Hageman"
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