5836554
doi
10.5281/zenodo.5836554
oai:zenodo.org:5836554
SEX-RELATED DIFFERENCES IN LONG COVID-19 SYNDROME
Pela' Giovanna
University of Parma
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
sex
gender
SARS CoV-2
Long-COVID-19 syndrome,
long-term outcome
<p>Background: Sex-differences have been demonstrated in the acute phase of COVID-19 infection; females (F) were found to be less prone to develop a severe disease than males (M), but few studies have assessed sex-differences in Long-Covid-19 syndrome.</p>
<p>Aim and Results: The aim of this prospective/retrospective study was to characterize the long- term consequences of this infection from a sex-perspective. For this purpose, we enrolled 223 patients (89 F and 134 M) who experienced a SARS -CoV-2 infection. In the acute phase of the illness, females reported more frequently than males: weakness, dysgeusia, anosmia, thoracic pain, palpitations, diarrhea, and myalgia without significant differences in breathlessness, cough, and sleep disturbance. After a mean follow-up time of 5 months after the acute phase, females were significantly more likely than males to report weakness, thoracic pain, palpitations, and sleep disturbance but not myalgia and cough.</p>
<p>At the multivariate logistic regression, women were statistically significantly likely to experience persistent symptoms such as dyspnoea, fatigue, chest pain, and palpitations. On the contrary, myalgia, cough and sleep disturbance were not influenced by sex.</p>
<p>Conclusion: We demonstrated that females were more symptomatic than males not only in the acute phase but also at follow-up. Sex was found to be an important determinant of Long-COVID syndrome because it is a significant predictor of persistent symptoms in females, such as dyspnoea, fatigue, chest pain, and palpitations.</p>
<p>Our results suggest the need for long-term follow-up of these patients from a sex-perspective in order to implement early preventive and personalized therapeutic strategies.</p>
Zenodo
2022-01-11
info:eu-repo/semantics/preprint
5836553
1641908929.759327
806024
md5:97733d75b363a8779763cb9eca372c6a
https://zenodo.org/records/5836554/files/manuscript Sex-related and Long-COVID-19.pdf
465401
md5:c9e7b6b5a6f97ac76cdd070784ad0a35
https://zenodo.org/records/5836554/files/Reply to the Reviewers Comments.pdf
public
10.5281/zenodo.5836553
isVersionOf
doi