FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF CHLORZOXAZONE USING DIFFERENT FILM FORMING AGENTS

Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant. Which are having shorter half life (1.1hour) with the dose administration of 3-4 times a day. Oral film of chlorzoxazone quickly disintegrates and dissolves and can be administered without water, making them particularly suitable for geriatric patients and found faster action. Fast dissolving oral films (FDOFs) have gained popularity not only in breath strips but also in personal care, food drug delivery markets. The aim of present work is to formulate and evaluate fast dissolving oral films of chlorzoxazone to improve water solubility, dissolution rate, oral bioavailability and reduction of first pass metabolism and increase patient’s compliance. Oral fast dissolving films prepared by solvent casting method using water and 95% ethanol as solvents and gelatin, xanthan gum, gum acacia as film forming polymer. Superdisintegrants such as croscarmellose sodium (CCS) was incorporated to achieve the aim. The prepared films were evaluated for the drug content, weight variation, film thickness, folding endurance, disintegration time, percentage of moisture content and in vitro dissolution studies and taste mask studies on healthy human volunteers. Among all, the formulation F6 was found to be best formulation which releases 98.85±0.25% of the drug within 360sec and disintegration time is 10±5sec. which was significantly high when compared to other formulation.

Keywords:  Chlorzoxazone, Fast dissolving oral film, Bioavailability, Mechanical properties