Proton-ligand stability constants of cefadroxil and stability constants of its metal complexes in aqueous-organic mixtures

Department of Biochemistry and Chemistry, Punjab Agricultural University, Ludhtana-141 004, PunJab, lndta

E-mail : sekhon224@yahoo.com

Manuscript received 4 January 2006, revised 27 July 2006, accepted 31 July 2006

Proton-ligand stability constants of cefadroxil and its metal-ligand stability constants with cu²+, Cd² and Co²+ ions were determined pH-metrically at 30 ºC and ionic strength of 0.15 M KCI in aqueous, water-alcohol (75 : 25% v/v) and water-dioxane (75 : 25% v/v) mixtures. Cefadroxil formed 1 : 1 (ML) complexs with Cd² and Co²+ whereas 1 : 2 (ML₂) with Cu²+ in aqueous,water-alcohol (75 : 25% v/v) and water-dioxane (75 : 25% v/v) mixtures.