FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLET OF TERBUTALINE SULPHATE BY NOVEL CO-PROCESSING

The present study was to formulation and optimization of fast dissolving tablet of terbutaline sulphate by novel co-processing, Terbutaline sulphate tablets containing co-processed superdisintegrants exhibited quick disintegration and improved drug dissolution. This formulation is more cost effective than aerosol inhalation pumps available. It was found that the total maximum amount of drug from the optimised batch was released in first 4 minutes of the dissolution study. The tablets disintegrated within 50 sec under experimental in vitro laboratory conditions. It can be concluded from the present work that co-processed superdisintegrants of crospovidone and croscarmellose are superior to physical mixture of crospovidone and croscarmellose used in Terbutaline sulphate fast dissolving tablets.

Keywords: Superdisintegrants, co-processing, disintegration time, excipients, capillary