Complexation behavior and stability of ternary complexes of glutathione and thymine involving HgII, PbII, CdII, ZnII, ColI and NiII metal ions

Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India

S. P. Memorial Institute of Technology, Kaushambi, Allahabad, Uttar Pradesh, India

E-mail : v.krishna20@rediffmail.com; pallavichandralO@yaboo.co.in; di_sri@yahoo.com

Manuscript received 5 June 2009, reised 8 February 2010, accepted 25 February 2010

The overall stability constants of ternary complexes of Hg^II, Pb^II, Cd^II, Zn^II, Co^II and Ni^ll with reduced glutathione and thymine have been determined in biologically relevant conditions and at an Ionic strength of 0.1 M NaNO₃. The stability constants and complexation equilibria have been determined on the bull of speciation curves obtained through SCOGS. The stability sequence of 1 : 1 : 1 GSH(A) : M(ll) : Thy(B) has been found as : GSH(A)·Hg^II-Tby(B) > GSH(A)·Pb^II-Tby(B) > GSH(A)-Cd^II -Thy(B) >GSH(A)-Zn^II-Tby(B) > GSH(A)-Co^II-Tby(B) > GSH(A)·Ni^II-Thy(B).