July 20, 2021 Journal article Open Access

Andrei Zinovyev

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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.5782911", 
  "container_title": "Physics of Life Reviews", 
  "language": "eng", 
  "title": "Adaptation through the lense of single-cell multi-omics data Comment on \"Dynamic and thermodynamic models of adaptation\" by A.N. Gorban et al.", 
  "issued": {
    "date-parts": [
      [
        2021, 
        7, 
        20
      ]
    ]
  }, 
  "abstract": "<p>A.N.Gorban and his colleagues in their inspiring review described several theoretical models of adaptation and&nbsp;highlighted multiple examples convincing us in the existence of surprising at first thought phenomenon: the pattern&nbsp;of dynamical changes of basic statistical measures (correlation between features, their variance) can diagnose and&nbsp;prognose crises in the populations of objects exposed to stress (1). The surprise is caused by the universality of this&nbsp;observation. Firstly, it is manifested in many different situations. Secondly and even more surprising, the features used&nbsp;do not have to be specifically designed to measure stress, even though the feature selection is still important. This&nbsp;suggests that the proposed models can serve as an insightful approach for Big Data analysis and interpretation.&nbsp;One can note that all provided examples deal with macroscopic objects (people, patients, mice, plants, companies&nbsp;at the stock market). What if we will change the focus of the middle-out approach to a significantly smaller scale, e.g.&nbsp;from a tumor or a patient to a single cell? Would the suggested principles of adaptation thermodynamics still hold and&nbsp;what specific problems will arise?</p>", 
  "author": [
    {
      "family": "Andrei Zinovyev"
    }
  ], 
  "page": "132-134", 
  "type": "article-journal", 
  "id": "5782911"
}