Synthesis of various pharma based pyrido[2,3-d]pyrimidine as well as pyrido[1,2-a]pyrimidine and their antimicrobial activities

Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India

E-mail : bhavana_mistryll@yahoo.co.in

Manuscript received 27 October 2008, revised 2 April 2009, accepted 7 August 2009

4-Amino-7-{ 4'-[(4" -methylplperazlnyl)dlazenyl)phenyi}-5-(snbstitutedphenyl)-1H-pyrldo[2,3-d]pyrimldine-2-one (4a-j), 4-amino-7-{4'-[(4"-methylpiperazinyl)diazenyl]phenyi}-5-(substitutedphenyl)-1H-pyrldo[2,3-d]pyrlmldhle-2-thlone (5a-j), 4-thioureido-7-{ if -[(4" -methylpiperazinyl)dlazenyl)phenyl}-5-(substitutedphenyl)-1H-pyrldo[2,3-d]pyrimldlne-2-thione (5a-j), 2-methy 1-7 -{ 4'-[ ( 4" -methyl plperazlnyl)dlazeny I) phenyl}-5-(substituted phenyl)-3H-pyrldo [2 ,3-d] pyrimidine-4-one (7a-j) and 4-methyl-5-{ 4'-[( 4"-methylplperazlnyl)dlazenyl]phenyl}-2-oxo-7-(substltutedphenyl)-2H-pyrldo[l,2-o] pyrimidine8-carbonitrile (8a-j) have been synthesized by the reaction or 2-amino-6-{4'-[(4"-methylpiperazinyl)dlazenyl)phenyl}-4- (substitutedpheuyl)pyrldlne-3-carbonltrlle (3) with urea, thiourea, ammonium thiocyanate, acetic anhydride and ethylacetoacetate respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures or novel synthesized compounds have been established on the basis of elemental analysis, 1H NMR and IR spectral data.