BUCCAL MUCOADHESIVE TABLET DRUG DELIVERY SYSTEM OF RIZATRIPTAN AGAINST SUSTAINABLE MIGRAINE BY USING METHOCEL K100LV, CARBOPOL 934P AND JAGUAR GUM: DESIGN, DEVELOPMENT AND IN VITRO EVALUATION

Abstract:

The present research was expected to foster buccal mucoadhesive tablet of Rizatriptan utilizing mucoadhesive polymers like Methocel K100LV, Carbopol 934P and Jaguar gum by direct pressure technique. The dry power combination of medication and polymers were assessed for precompression parameters to guarantee flow properties during tablet compression. FTIR and DSC results showed no proof of interaction between the Rizatriptan and mucoadhesive polymers utilized for formulations. The detailed mucoadhesive buccal tablets were assessed for physicochemical properties like hardness, friability, thickness consistency, weight variation, swelling studies and moisture absorption studies. The formulated buccal tablets were additionally assessed for mucoadhesive strength, in vitro drug delivery and ex vivo drug permeation through cellulose acetic acid derivation layer. Ex vivo mucoadhesive strength and in vitro discharge studies showed that formulation RBMT₄ containing 20% of Methocel K100LV and 10% of Jaguar gum showed adequate bioadhesive strength and displayed optimum medication release (99.64% after 10hrs). The Stability of best mucoadhesive buccal still up in the air in artificial human saliva and it was found that both Rizatriptan and buccal tablets were steady in human saliva. The plan mucoadhesive buccal tablets of Rizatriptan expected to have delayed restorative impact with improved tolerance consistence by keeping away from first pass metabolism.

Keywords: Antimigraine, Mucoadhesion, Rizatriptan, Methocel K100LV, Carbopol 934P, Jaguar gum