FORMULATION AND IN-VITRO EVALUATION OF TASTE MASKED ORALLY DISINTEGRATING TABLETS OF A BITTER BCS CLASS II DRUG

The present study concerns to mask the bitter taste of Ibuprofen as an orally disintegrating tab-let using Eudragit EPO (Film former) as a taste masking agent. FT-IR spectrometries were used to investigate the compatibility of drug: resin complex. Six batches (F1, F2, F3, F4, F5, and F6) of orally disintegrating tablets were prepared by wet granulation method with super disintegrant like Crosscarmellose sodium, Crospovidone. The granules were evaluated for pre-compression parameters like angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. And post-compression parameters like weight variation, thickness, hardness, friability, and in-vitro disintegration and in-vitro dissolution tests. The results indicate that orally disintegrating tablets of Ibuprofen containing Eudragit EPO provides good taste and better option for quick disintegration and fast release and improved bioavailability. Therefore to ensure faster drug release, a water soluble excipient, lactose was added to the pellets. Coating of Ibuprofen loaded MCC-Lactose pellets with Eudragit EPO masked the taste and increased the drug release profile by 12% in 30 min.