Synthesis of some biologically active pyrimidine and isoxazole derivatives

Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India

E-mail : bhavana_mistry11@yahoo.co.in

Manuscript received 04 July 2012, revised 07 July 2014, accepted 10 July 2014

4-(2,5-Dichloro-3-thienyl)-6-substitutedphenylpyrimidine-2(1H)-thione (2a-j), 3-(2,5-dichloro-3-thienyl)-5- substitutedphenyl-4,5-dihydroisoxazole (3a-j) have been synthesized by the reaction of (2E)-1-(2,5-dichloro-3-thienyl)-3- substitutedphenylprop-2-en-1-one (1) with thiourea and hydoxylamine hydrochloride respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, ¹H NMR, ¹³C NMR and mass spectral data.