Journal article Open Access
I. Rama; Selvameena Ramaswami
P.G. and Research Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli-620 002,
E-mail : firstname.lastname@example.org, email@example.com Fax : 91-431-2704596
Manuscript received online 15 April 2014, revised 25 April 2014, accepted 05 May 2014
Two new Schiff base ligands formed by the condensation of 5-bromosalicylaldehyde with sulfapyridine and sulfathiazole and their metal complexes of CoII, NiII and CuII were synthesized and characterized by elemental analysis, molar conductance, thermal studies, magnetic moment, EPR, IR, 1H NMR, 13C NMR, mass and electronic spectral data. Both ligands are bidentate, coordinating through azomethine nitrogen and hydroxyl oxygen after deprotonation. These compounds were screened for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Bacillus subtilis), Gram-negative (Pseudomonas aeruginosa, E. coli, Klebsiella sp.) bacterial strains and for in vitro antifungal activity againt Aspergillus niger, Mucor sp. and Candida albicans. The results of these studies revealed that all complexes exhibited significant to moderate antibacterial activity. All the complexes exhibit six coordinated octahedral geometry.