FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CLONAZEPAM USING NATURAL AND SYNTHETIC SUPER DISINTEGRANTS

In this work, natural and synthetic super disintegrants were used to produce mouth dissolving tablets for anticonvulsant drugs utilizing the direct compression method. Plantago ovate mucilage (2-8%) was employed as a natural super disintegrant, while Cross carmellose sodium (2-8%) was used as a synthetic super disintegrant in the direct compression method. Extracting the drug with 0.1 N HCl and pH 6.8 phosphate buffer and measuring the absorbance at 254nm was used to estimate the anticonvulsant drug in the produced tablet formulations.

After that, post-compression parameters were tested on the prepared formulations.

In vitro drug release pattern (0.1 N HCl and pH 6.8 phosphate buffer), stability study (at 40°C/75% RH for 6 months), drug-excipient interaction (IR spectroscopy), and in vitro dispersion time were all compared to formulations including natural super disintigrant.

The overall best formulation formulations were those that contained 8% w/w natural super disintegrant Plantago ovate mucilage (FM8).

Short-term stability analysis of potential formulations revealed that drug content and In vitro dispersion time did not change significantly. There are no drug-excipient interactions, according to IR spectroscopic tests. Natural super disintegrants were found to be superior in compression to synthetic super disintegrantes with enhanced dissolving in the current study.

Keywords: Clonazepam, Plantago ovata mucilage, Cross carmellose sodium.