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OVERVIEWS ON ANALYTICAL METHODS OF ANAGLIPTIN AND METFORMIN HYDROCHOLRIDE

Khushbu S. Patel, Dr.Sejal G. Patel and Dr. Richa Dayaramani

Antidiabetic drugs used in diabetes to treat diabetes mellitus by lowering the glucose level in the blood. Antidiabetic drugs mainly classify in oral hypoglycemic agent and insulin preparation. Where Anagliptin and Metformin HCl both drugs are oral hypoglycemic agents. In the Anagliptin is Dipeptidyl peptidase-4 inhibitors is also known as gliptins class and Metformin belong to bigunide, combination of Anagliptin and Metformin HCl give interactive effect and also homeostasis model assessment of Beta-index. Many Analytical Methods developed for single Metformin HCl & Anagliptin. Metformin is official in IP, BP, USP, and other methods like….UV, SPECTROPHOTOMETRIC, RP-HPLC, LC-MS,MS/MS  are also developed. Anagliptin is not official in any pharmacopeia but ELISA, NMR, UV, LC/MS are developed. In combination of Anagliptin and Metformin HCl for first order derivative UV method is developed.

Key Words: Analytical Methods, Anagliptin, Metformin HCl

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