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STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF FEXOFENADINE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

D.Chinababu, K. Supraveena*, L. Siva Shankar Reddy, C. Madhusudhana Chetty, N. Madan Gopal


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{
  "description": "<p><em>A simple, rapid and accurate method was developed for the determination of Fexofenadine Hydrochloride in bulk and pharmaceutical dosage form by RP-HPLC method using C<sub>18</sub> column [4.6&times;250mm,5&mu;m] in binary gradient mode.&nbsp; The mobile phase consisted of methanol and water in the ratio of 80:20 v/v. The flow rate was maintained at 1.2&nbsp;mL/min and wavelength was maintained at 220 nm. The column oven temperature was maintained at 40&deg;c. The retention time of Fexofenadine Hydrochloride was attained at 2.96 min. The method was linear over the concentration range from 7.5-40&mu;g/mL and R<sup>2 </sup>was found to be 0.999. The intraday and interday precision %RSD values were obtained &lt;2.0. The LOD and LOQ were attained at 0.603 and 1.829&mu;g/mL respectively. The accuracy results of the method&nbsp;was obtained 98.37-99.84% at different levels of concentrations. The method was proved as robust after deliberately changed parameters of flow rate, mobile phase composition, temperature and wavelength. The method was shown ability to&nbsp;words different stress conditions of acid, base, peroxide and UV-Light. The method was used for routine analysis of Fexofenadine hydrochloride in pharmaceutical dosage form.</em></p>\n\n<p><strong><em>Key Words:</em></strong><em> Fexofenadine hydrochloride, RP-HPLC, Methanol, Stability studies.</em></p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "D.Chinababu, K. Supraveena*, L. Siva Shankar Reddy, C. Madhusudhana Chetty, N. Madan Gopal"
    }
  ], 
  "headline": "STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF FEXOFENADINE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM BY USING   RP-HPLC", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2021-11-23", 
  "url": "https://zenodo.org/record/5720873", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.5720873", 
  "@id": "https://doi.org/10.5281/zenodo.5720873", 
  "@type": "ScholarlyArticle", 
  "name": "STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF FEXOFENADINE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM BY USING   RP-HPLC"
}
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