Journal article Open Access
Bhavana Singh and Saranjit Singha*
The objective of present investigation is to prepare and optimize an oral floating alginate gel beads of Sitagliptin phosphate using sodium alginate and oils as a dispersed phase to generate a uniform emulsion to create multiple tiny chambers in the alginate matrix for better buoyancy. Sitagliptin phosphate loaded beads were prepared by emulsion gelatin method. In this method pre gelation liquid of sodium alginate solution (2-4% w/v) was prepared. Oil (olive oil) in the concentration 30%, was then added to the polymer solution. From the results formulation F-3, F-7 and F-8 was chosen as the most optimized formulation as it possessed all the required physicochemical characters and sustained drug release. The in vitro release data fitted with higher values in matrix model and the release was found to be Non- Fickian diffusion (anomalous transport) as the n value is in between 0.5 to 1. Entrapment efficiency and drug release of optimized batch F-3, F-7 and F-8 was found to be 78.22% and 92.63% respectively. Drug absorption from the gastrointestinal tract is highly variable process and prolonging gastric retention of the dosage form is a challenging task. Under such circumstances, floating drug delivery system proves to be promising approach for gastric retention. The optimization of floating, drug entrapment efficiency and drug release behaviour of Sitagliptin phosphate beads was done by applying design expert.